- "We've got to make a human centipede of our prisoners, sewn ass-to-mouth, sharing one digestive system. No more prison fights. No more assaults on guards. No more disrespect. They will literally be on their knees begging for your mercy."
- —Dwight Butler to Bill Boss[src]
George H.W. Bush State Prison is the primary setting of The Human Centipede 3 (Final Sequence). It is a penitentiary located in the United States of America. The prison is headed by the sadistic warden known as Bill Boss. It is where Boss, along with his accountant Dwight Butler, decide to create a 500-person centipede using the prisoners.
- The name of the prison is an obvious reference to George H. W. Bush, the 41st President of the United States.