- "The Human Caterpillar! For all the life time convicts and our friends on death row. Now, is that a deterrent?"
- —Bill Boss[src]
The Human Caterpillar is a supplementary creation to the human prison centipede in The Human Centipede 3 (Final Sequence), intended for the prisoners on death row at George H.W. Bush State Prison. The concept was thought of by Bill Boss and basically consists of a smaller human centipede with the limbs of the segments surgically amputated, taking away the prisoners' sense of control over their own selves and preventing most physical movements.
- Although The Human Centipede 3 (Final Sequence) marks the final film in the Human Centipede series, creator Tom Six has expressed an interest in making a Human Caterpillar film featuring a female lead and a female villain. According to Tom Six, if he ever makes the Human Caterpillar film, the film will be shot in Japan.